Endocrine Abstracts

Introduction: With the wider availability of imaging techniques there is an increasing number of newly diagnosed, accidentally found pathological formations in the adrenal glands known as adrenal incidentaloma (AI). Currently, the professional consensus is that hormonally active incidentalomas and those suspicious of malignancy should be indicated for surgery.Methods: In our retrospective study, we analyzed data of 141 patients with a total of 160 AIs, w...

Introduction: Scintigraphy had long been the only modality for thyroid gland imaging. With the development of other imaging techniques (sonography, CT, MRI), the role of scintigraphy has gradually diminished. However, it cannot be completely ignored, as it is the only technique to image not only the morphological structure, but also the functional status of the thyroid gland. In the current clinical practice, thyroid scintigraphy is performed with 99mTc pertechnetat...

Amiodarone is a potent and among cardiologists still very popular anti-arrhythmic drug. This case report describes severe course of amiodarone-induced thyrotoxicosis (AIT) which is one of the most serious side effects of the treatment. The patient (J S born in 1950) was first hospitalised in June 2012 for atrial fibrillation with rapid ventricular response and tachycardia-induced cardiomyopathy with a decreased ejection fraction (EF). Thyroid hormones were normal at that time ...

We present two case reports of patients who were diagnosed with hyperparathyroidism based on a parathyroid gland adenoma (PTA). The pathological parathyroid tissue was precisely localised by ultrasonography and scintigraphy before the surgery. In both cases all four parathyroid glands were revised by the surgeon resulting in an operation extension. Another parathyroid gland was removed and histologically confirmed as PTA. This surgeon’s approach was beneficial for the pat...

Normocalcaemic primary hyperparathyroidism (NPHPT) is becoming more common nowadays due to the increasing use of screening laboratory methods. In the care of the outpatient office of endocrinology of the 2nd Department of Internal Medicine, Faculty of Medicine, Masaryk University and St. Anne’s University Hospital in Brno in the period between 1 January 2007 and 31 December 2019, there were a total of 304 patients diagnosed with primary hyperparathyroidism. At the time o...

Introduction: The estimation of urinary aldosterone is one of the recommended confirmatory tests when diagnosing primary aldosteronism (PA). The study assessed the interpretation of the urinary aldosterone secretion (UA).Subjects and methods:: The study enrolled both healthy volunteers and patients with suspected PA. Estimation of UA in 24-hour urine specimen was performed in enrolled individuals. Increased oral salt intake was recommended before and dur...

Levothyroxine suppression therapy, i.e. keeping the TSH value below 0.3 mIU/l with the aim to reduce the total thyroidal tissue or nodule volume, is an arguable and controversial issue not only due to the effect upon nodule volume but also because of the extent of necessary suppression, the effect of incomplete suppression, long-time therapeutic effects and risk of cardiovascular problems and osteoporosis.The incidence of nodular alterations rises with a...

For a long time it has been suggested that glucocorticoids (GC) mediate their effects solely on the genomic level. A number of studies reported an existence of rapid GC effects independent on gene expression. These effects may play an important role in stress response or during acute GC therapy. As far as we know, rapid inhibitory GC effects on glucose-induced secretion of insulin have been reported only in animals (1). The aim of our study was to evaluate effects of GC on ear...

CA19-9 (sialyl Lewis[a] antigen) was originally described as a gastrointestinal system and pancreas specific tumour marker. Immunohistochemical studies have demonstrated that CA19-9 is expressed in both differentiated and anaplastic thyroid carcinomas. Increased serum levels of CA 19-9 were reported in few patients with anaplastic thyroid cancer; however, to the best of our knowledge, there is no previous report about serum levels of CA 19-9 in differentiated thyroid cancer. S...

The 5α-reductase is one of the enzyme of steroid synthesis and founded in two isoformes. Two distinct 5α-reductase isoenzymes, type I and type II, are found across mammalian species. Each of these isoenzymes is differentially expressed in tissues and during distinct developmental stages and also in different species. The 5α-reductase is enzyme responsible for the reduction of testosterone to dihydrostestosterone, progesterone to dihydroprogesterone and deoxycort...